California's proposition 65

Methanol: Proposition 65: Comments on Proposed Madls

We are providing comments on the Office of Environmental Health Hazard Assessment’s (OEHHA) March 16, 2012 “Notice of Proposed Amendment to Section 25805(b), Specific Regulatory Levels: Chemicals Causing Reproductive Toxicity: Methanol”. We truly appreciate the opportunity to comment on the proposed MADLs. These comments are being submitted on behalf of a coalition that includes the following i...

A Proposition 65 Risk Evaluation of Lead in @@ Guitar Strings

No Significant Risk Level (nsrl) for the Proposition 65 Carcinogen Polygeenan

The cancer potency of polygeenan was estimated from dose-response data of colorectal tumors among male and female rats exposed orally (Wakabayashi et al., 1978). The cancer potency estimate corresponds to the upper 95 percent confidence bound on the linear term of the multistage model fit to cancer dose-response data in animals. The potency derivation takes into account body size differences be...

No Signficant Risk Level (nsrl) for the Proposition 65 Carcinogen Tetranitromethane

Using the default procedures outlined in Title 22 (California Code of Regulations, Section 12703), the Office of Environmental Health Hazard Assessment (OEHHA) derived a human cancer potency estimate of 12 (mg/kg-day) for tetranitromethane. The potency derivation takes into account body size differences between humans and experimental animals. The Proposition 65 “no significant risk level” (NSR...

No Significant Risk Levels (nsrls) for the Proposition 65 Carcinogens Lead and Lead Compounds (oral)

This document provides a basis for the estimation of cancer risk from exposure to lead. Carcinogenic potencies were estimated from oral studies of the carcinogenicity of lead compounds. These estimated potencies were based upon the administered doses of lead; in some cases, it was necessary to calculate lead dose based upon the lead content of the administered compounds. The uncertainty associa...